N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the

Details N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the

1993-11-24

1994-11-15

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

562 21, A61K 3166, C07F 938

Patent

active

053648463

ABSTRACT:
Substituted aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphosphinophosphonic acids, processes for their preparation and use thereof
The invention relates to compounds of the formula I ##STR1## in which R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are a hydrogen atom or (C.sub.5 -C.sub.5)-alkyl, m is the integer 0 or 1, x is (C.sub.1 -C.sub.10)-alkyl, mono- or polysubstituted, a 5- or 6-membered ring having one nitrogen atom and optionally a further nitrogen or oxygen atom; aryl having 6 or 10 carbon atoms, which can be substituted; or cycloalkyl, to processes for the preparation of the compound of the formula I; to pharmaceuticals, and to their use for the treatment of osteoporosis and degenerative joint diseases.

REFERENCES:
patent: 4814326 (1989-03-01), Rosini et al.
patent: 5133972 (1992-07-01), Ferrini et al.
D. Burkhardt et al., Current Therapeutic Research, vol. 40, No. 6, (1986), S. 1034 ff.
Modern Synthetic Reactions, 2nd Ed., W. A. Benjamin, Inc., pp. 595-623 (1972).
Chemical Abstracts, American Chemical Society (1992), Accession No. 93(9): 933610, I. S. Alferey et al. "Immunodepressive effect of N-substituted 2-aminoethylidene-1,1-diphosphonic acids".

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