N-carboxymethyl substituted lysyl and .alpha.-(.epsilon.-aminoal

Details N-carboxymethyl substituted lysyl and .alpha.-(.epsilon.-aminoal N-carboxymethyl substituted lysyl and .alpha.-(.epsilon.-aminoal

1983-02-07

1986-07-22

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 10, 544 50, 2609982, 546147, 546165, 546245, 546341, 548186, 548188, 548201, 548379, 548408, 548452, 548491, 548899, 548532, A61K 31405, A61K 3702, C07D20708

Patent

active

046020020

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.2 is --(CH.sub.2).sub.k --X--(CH.sub.2).sub.j --NHR.sup.3 ; wherein k is 0 to 3, j is 1 or 2; X is F or OH; and, R.sup.3 is hydrogen; loweralkyl or loweraralkyl which may be substituted by hydroxy, carboxy, carbamoyl, or carbalkoxy; or, acyl; and, a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.

REFERENCES:
patent: 4470973 (1984-09-01), Natarajan et al.

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