N-carbobenzyloxy (N-CBZ)-deprotecting enzyme

Details N-carbobenzyloxy (N-CBZ)-deprotecting enzyme N-carbobenzyloxy (N-CBZ)-deprotecting enzyme

2006-08-10

2008-08-26

Swope, Sheridan (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S068100

Reexamination Certificate

active

07416876

ABSTRACT:
This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.

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Matsumura, E. et al., “A Novel Enzyme “Nα-Benzyloxycarbonyl amino acid urethane hydrolase II” fromLactobacillus fermenti36 ATCC 93381)” Chem. Pharm. Bull., vol. 33(1), pp. 408-411 (1985).

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