N-.beta.-(2-a cetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benzyl

Details N-.beta.-(2-a cetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benzyl N-.beta.-(2-a cetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benzyl

1973-05-18

1976-05-11

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605676M, 424329, C07C 9314

Patent

active

039563693

ABSTRACT:
A compound N-.beta.(2-acetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benzylammonium-p-c hlorobenzene sulphonate having the formula: ##SPC1##
This compound is prepared by reacting 2-hydroxy-5-chloroacetophenone and .beta.-dimethylaminoethyl chloride with heating in a medium of an organic solvent in the presence of an alkali agent, reacting the resulting 2-acetyl-4-chlorophenoxyethyl-dimethylamine with benzyl chloride, and subsequently reacting the resulting N-.beta.-(2-acetyl-4-chlorophenoxy)-ethyl-N,N-dimethyl-N-benylammonium chloride with a sodium salt of p-chlorobenzene sulphonic acid.
This compound exhibits anthelmintic activity for Trichocephalus muris in albine mice.

REFERENCES:
patent: 1867022 (1932-07-01), Mune et al.
patent: 3328464 (1967-06-01), Gundel et al.
patent: 3714256 (1973-01-01), Samour et al.
Chem. Abstracts, 8th Collective Index, Vol. 66-75, p. 20825 (1967-1971); Krotov et al, Chem. Abs., 70, 46407m (1969).
Petkov et al, Chem. Abstract, 75, 40426y (1971).

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