Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-22
1997-02-18
Hamilton, III, Thomas
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548469, 548494, 548509, 548510, A61K 31405, C07D20904, C07D20910
Patent
active
056042531
ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
REFERENCES:
patent: 3161654 (1964-12-01), Shen
patent: 3196162 (1965-07-01), Sarett et al.
patent: 3242163 (1966-03-01), Sarett et al.
patent: 3654349 (1972-04-01), Shen et al.
patent: 3725548 (1973-04-01), Shen et al.
Chem. Abstracts, vol. 61, p. 4320 (a) (1964) "Resolution of Substituted Indoles" 1-p-chlorobenzyl-2-methyl-5-methoxy-3-indolyl)propionic acid.
Black Cameron
Ducharme Yves
Gauthier Jacques Y.
Guay Daniel
Hamel Pierre
Hamilton, III Thomas
Merck Frosst Canada Inc.
Panzer Curtis C.
Rose David L.
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