N-Benzyl-imidazoles as selective inhibitors of the thromboxane s

Details N-Benzyl-imidazoles as selective inhibitors of the thromboxane s N-Benzyl-imidazoles as selective inhibitors of the thromboxane s

1981-07-27

1984-05-15

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548252, C07D25704, A61K 3141

Patent

active

044487819

ABSTRACT:
The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.

REFERENCES:
patent: 3498999 (1970-03-01), Buchanan et al.
patent: 4118487 (1978-10-01), Regal et al.
patent: 4183742 (1980-01-01), Sasse et al.
Buchanan et al., J. Med. Chem., vol. 12, Nov. 1969, p. 1001.
Tai et al., "Biochemical and Biophysical Res. Comm., vol. 80, No. 1, 1978, pp. 235-243.
Johnson et al., J. Med. Chem. 12, 1024 (1969).
Baggaley et al., J. Med. Chem. 18, 833 (1975).

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