N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S438000, C548S131000, C549S077000

Reexamination Certificate

active

10500811

ABSTRACT:
The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

REFERENCES:
patent: 4774251 (1988-09-01), Hirsch et al.
patent: 6437165 (2002-08-01), Mandala et al.
patent: 2446593 (2002-11-01), None
patent: 0 791 576 (1997-08-01), None
patent: WO 02/18395 (2002-03-01), None
Kiuchi, M., et al, Journal of Medicinal chemistry, American Chemical Society, vol. 43, pp. 2946-2961, XP 002271142, 2000.
Nicolaus B.J.R.: “Symbiotic approach to drug design”, Decision Making in Drug Research, 1983, pp. 173-186, XP002197412.

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