N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment o

Details N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment o N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment o

1986-03-31

1988-02-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514232, 514255, 514331, 514428, 514471, 514522, 514586, 514595, 514821, A61K 3155, A61K 31495, A61K 31445, A61K 31535

Patent

active

047242353

ABSTRACT:
N-(Arylthioalkyl)-N'-(aminoalkyl)ureas and thioureas and oxidation derivatives having the formula ##STR1## wherein B is thio, sulfinyl or sulfonyl; R.sup.1 and R.sup.2 are hydrogen, loweralkyl, cycloalkyl, 2-furanyl, phenyl, substituted phenyl or phenyl-loweralkyl and R.sup.3 and R.sup.4 are hydrogen, loweralkyl, phenyl or phenyl-loweralkyl wherein phenyl is optionally substituted, or R.sup.3 and R.sup.4 taken with the adjacent nitrogen form a heterocyclic residue. The compounds are useful in the treatment of cardiac arrhythmia.

REFERENCES:
patent: 2344934 (1944-03-01), West
patent: 4279911 (1981-07-01), Smith et al.
patent: 4500529 (1985-02-01), Shanklin et al.
patent: 4558155 (1985-12-01), Shanklin et al.
Koelzer et al., Arzneim. Forsch. 9, pp. 113-120 (1959).

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