Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-31
1997-08-12
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514352, 546309, 544332, 544329, 544322, A61K 3144, C07D21338, C07D23942
Patent
active
056566344
ABSTRACT:
Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
REFERENCES:
patent: 3969362 (1976-07-01), Takahashi
patent: 4743605 (1988-05-01), Hoefle
patent: 5142094 (1992-08-01), O'Brien
Chang George
Hamanaka Ernest S.
McCarthy Peter A.
Truong Thien V.
Walker Frederick J.
Bekelnitzky Seymour G.
Ginsburg Paul H.
M. Mach D. Margaret
Pfizer Inc.
Richardson Peter C.
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