N-aralkyl piperidine methanol derivatives and the uses thereof

Details N-aralkyl piperidine methanol derivatives and the uses thereof N-aralkyl piperidine methanol derivatives and the uses thereof

1987-07-07

1988-11-08

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514331, A61K 31445

Patent

active

047834714

ABSTRACT:
This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5HT.sub.2 receptor site, and to the processes for their preparation and use.

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patent: 3029244 (1962-04-01), Lyle et al.
patent: 3037986 (1962-06-01), Langis et al.
patent: 3100775 (1963-08-01), Rorig
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patent: 4569941 (1986-02-01), Sun et al.
Derwent Abstract 78-14451A (Abstract of French Pat. No. 2,350,341).
Derwent Abstract 66-00470F (Abstract of British Pat. No. 843,070).
R. E. Lyle, H. S. Troscianiec and G. H. Warner, J. Org. Chem. 24, 338-42 (1959).
A. E. Petrarca, U Org Chem. 24, 1171-72 (1959).

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