N- and C-terminal truncation and deletion mutants of human inter

Details N- and C-terminal truncation and deletion mutants of human inter N- and C-terminal truncation and deletion mutants of human inter

1993-11-08

1996-05-14

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

530351, 435 6952, 930141, 930145, A61K 3820, C07K 1454

Patent

active

055165125

ABSTRACT:
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred substitution mutants include Cys.sup.16 .fwdarw.Ala.sup.16 and/or Cys.sup.84 .fwdarw.Ala.sup.84, Glu.sup.50 .fwdarw.Lys.sup.50 and Lys.sup.79 .fwdarw.Glu.sup.79. These mutants can be used to formulate pharmaceutical compositions. Also disclosed are antibodies directed against specific epitopes localized between amino acids 29 and 54.

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