N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544360, 544367, 544389, 544391, C07D41300

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active

057314381

ABSTRACT:
Compositions comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups are prepared. The compounds of the present invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.

REFERENCES:
patent: 3947447 (1976-03-01), Glamkowski
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5449754 (1995-09-01), Nishioka
patent: 5472672 (1995-12-01), Brennan
patent: 5489678 (1996-02-01), Fodor et al.
patent: 5506337 (1996-04-01), Summerton et al.
patent: 5574017 (1996-11-01), Gutheil
Achari et al., "Facing up to Membranes: Structure/Function Relationships in Phospholipases", Cold Spring Harbor Symp. Quant. Biol., 1987, 52, 441-452.
Bomalaski et al., "Human Extracellular Recombinant Phospholipase A.sub.2 Induces an Inflammatory Response in Rabbit Joints", J. Immunol., 1991, 146(11), 3904-3910.
Burack et al., "Role of Lateral Phase Separation in the Modulation of Phospholipase A.sub.2 Activity", Biochemistry, 1993, 32, 583-589.
Campbell et al., "Inhibition of Phospholipase A.sub.2 ; a Molecular Recognition Study", J. Chem. Soc. Chem. Commun., 1988, 1560-1562.
Cho et al., "The Chemical Basis for Interfacial Activation of Monomeric Phospholipases A.sub.2 ", J. Biol. Chem., 1988, 263(23), 11237-11241.
Davidson et al., "Inhibition of Phospholipase A.sub.2 by Lipocortins and Calpactins", J. Biol. Chem., 1987, 262(4), 1698-1705.
Davidson et al., "1-Stearyl,2-Stearoylaminodeoxy Phosphatidylcholine, A Potent Reversible Inhibitor of Phospholipase A.sub.2 ",Biochem. Biophys. Res. Commun., 1986, 137(2), 587-592.
Dennis, E.A., "Phospholipases", The Enzymes, Boyer, P.D. (ed.), Academic Press, New York, 1983, vol. 16, 307-353.
Essien, H., "Synthesis of Diethylenetriaminepentaacetic Acid Conjugated Inulin and Utility for Cellular Uptake of Liposomes", J. Med. Chem., 1988, 31, 898-901.
Franson et al., "Phospholipid metabolism by phagocytic cells. Phospholipases A.sub.2 associated with rabbit polymorphonuclear leukocyte granules", J. Lipid Res., 1974, 15, 380-388.
Glaser et al., "Phospholipase A.sub.2 enzymes: regulation and inhibition", TiPs Reviews, 1993, 14, 92-98.
Grainger et al., "An enzyme caught in action: direct imaging of hydrolytic function and domain formation of phospholipase A.sub.2 in phosphatidylcholine monolayers", FEBS Lett., 1989, 252 (1,2), 73-82.
Lombardo et al., "Cobra Venom Phospholipase A.sub.2 Inhibition by Manoalide", J. Biol. Chem., 1985, 260(12), 7234-7240.
Marki et al., "Differential inhibition of human secretory and cytosolic phospholipase A.sub.2 ", Agents Actions, 1993, 38, 202-211.
Miyake et al., "The Novel Natural Product 4-hydroxyphenyl)chroman!: A Competitive Inhibitor of Group II Phospholipase A.sub.2 ", J. Pharmacol. Exp. Ther., 1992, 263(3), 1302-1307.
Noel et al., "Phospholipase A.sub.2 Engineering. 3. Replacement of Lysine-56 by Neutral Residues Improves Catalytic Potency Significantly, Alters Substrate Specificity, and Clarifies the Mechanism of Interfacial Recognition", J. Am. Chem. Soc., 1990, 112, 3704-3706.
Oinuma et al., "Synthesis and Biological Evaluation of Substituted Benzenesulfonamides as Novel Potent Membrane-Bound Phospholipase A.sub.2 Inhibitors", J. Med. Chem., 1991, 34, 2260-2267.
Pruzanski et al., "Enzymatic Activity and Immunoreactivity of Extracellular Phospholipase A.sub.2 in Inflammatory Synovial Fluids", Inflammation, 1992, 16(5), 451-457.
Sampson, B.A. et al., "Identification and Characterization of a New Gene of Escherichia coli K-12 Involved in Outer Membrane Permeability", Genetics, 1989, 122, 491-501.
Scott et al., "Interfacial Catalysis: The Mechanism of Phospholipase A.sub.2 ", Science, 1990, 250, 1541-1546.
Pon, R.T., "Solid Phase Supports in Oligonucleotide Synthesis", Protocols for Oligonucleotides and Analogs: Synthesis and Properties, Agrawal, S., ed., Humana Press, 1993, 20, 465-496.
Tanaka et al., "A Novel Type of Phospholipase A.sub.2 Inhibitor, Thielocin Al.beta., and Mechanism of Action", J. Antibiotics, 1992, 45(7), 1071-1078.
Vishwanath et al., "Edema-Inducing Activity of Phospholipase A.sub.2 Purified from Human Synovial Fluid and Inhibition by Aristolochic Acid", Inflammation, 1988, 12(6), 549-561.
Vloon, W.J. et al., "Synthesis and Biological Properties of Side-Chain-Modified Bleomycins", J. Med. Chem., 1987, 30, 20-24.
Washburn et al., "Suicide-inhibitory Bifunctionally Linked Substrates (SIBLINKS) as Phospholipase A.sub.2 Inhibitors", J. Biol. Chem., 1991, 266(8), 5042-5048.
Wery et al., "Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A.sub.2 at 22 .ANG. resolution", Nature, 1991, 352, 79-82.
Yang et al., "Studies on the status of lysine residues in phospholipase A.sub.2 from Naja naja atra (Taiwan cobra) snake venom", Biochem. J., 1989, 262,855-860.
Yuan et al., "Synthesis and Evaluation of Phospholipid Analogues as Inhibitors of Cobra Venom Phospholipase A.sub.2 ", J. Am. Chem. Soc., 1987, 109, 8071-8081.
Yuan, J. et al., "Syntheses of Some 2-Substituted Aminobenzothiazoles", Acta Scientiarum Naturalium, (Beijing Daxue Zuebao, Ziran Kexueban), 1988, 24(4), 504-506 (English Abstract).

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