N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidine

Details N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidine N-(amino)alkyl)-1-pyrrolidine, 1-piperidine and 1-homopiperidine

1985-07-01

1987-02-10

Michl, Paul R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546236, 548541, 548570, 540604, 540607, 540609, 540610, C07D21146

Patent

active

046423486

ABSTRACT:
Novel pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds having the formula: ##STR1## wherein X is --S--, --S(O)-- or --S(O).sub.2 --; A is a loweralkalene chain and A.sup.1 and A.sup.2 are alkalene chains when p and d are one; R, R.sup.1 and R.sup.2 are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R.sup.1 and R.sup.2 may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts useful as cardiac antiarrhythmia agents are disclosed.
Novel chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with --(A.sup.2).sub.p --X--(A.sup.2).sub.d --Q side chain are also disclosed.

REFERENCES:
patent: 4065584 (1977-12-01), Lafon
patent: 4294841 (1981-10-01), Champseix

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