N-.alpha.Methylcyclopropylmethyl derivatives of normorphine and

Details N-.alpha.Methylcyclopropylmethyl derivatives of normorphine and N-.alpha.Methylcyclopropylmethyl derivatives of normorphine and

1978-05-24

1980-08-19

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 44, A61K 31485, C07D48902

Patent

active

042184541

ABSTRACT:
Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives have strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.

REFERENCES:
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patent: 2741614 (1956-04-01), Clark
patent: 3393197 (1968-07-01), Pachter et al.
patent: 3468891 (1969-09-01), Bartels-Keith et al.
patent: 3676557 (1972-07-01), Lachman et al.
Clark et al., J. Am. Chem. Soc., vol. 75, pp. 4963-4966 (1953).
Winter et al., Arch. Int. Pharmacodyn. CX No. 2-3, pp. 186-202 (1957).
Loew et al., Opiates Endog. Opiod. Pept. Proc. Int. Narc. Res. Club Meet. 1976, 399-402, Abstract CA V. 87, 127012g.

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