N-alkylated carboxylic acid derivatives as anti-convulsant agent

Details N-alkylated carboxylic acid derivatives as anti-convulsant agent N-alkylated carboxylic acid derivatives as anti-convulsant agent

1982-03-15

1984-02-21

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, 424311, 424320, 424322, 546245, 546247, 546248, 548531, 548538, 548568, 548573, A61K 31445, C07D21114

Patent

active

044329857

ABSTRACT:
Described are compounds of the formula ##STR1## wherein R is hydrogen or loweralkyl; R.sub.1 is --OR.sub.2 or --NR.sub.2 R.sub.3 wherein R.sub.2 and R.sub.3 independently of one another denote hydrogen or loweralkyl; n is 0 or 1; R.sub.4 and R.sub.5 independently of one another denote loweralkyl or together form a 5 or 6 membered cycloalkyl substituted by hydrogen or loweralkyl, and together with the nitrogen atom, form a ring; and pharmaceutically acceptable salts thereof and their use as anticonvulsant agents in a method of controlling convulsions or seizures.

REFERENCES:
Chemical Abstracts, 65:15345c (1966) [Neth. Appl. 6,514,223, Sandoz, 5/6/66].
Chemical Abstracts, 57:16573b (1962) [Belg. 611,643, Bayer, 6/18/62].
Chemical Abstracts, 54:11012d (1960) [Nazarov et al., Zhur. Obshchei Khim., 29,2508-12 (1959)].
Chemical Abstracts, 77:151943a (1972) [Fr. Demande 2,095,399, Tilles, 3/17/72].
Chemical Abstracts, 89:101904r (1978) [Japan Kokai 7824,023, Fujimoto et al., 3/6/78].
Conant; J., The Chemistry of Organic Compounds, MacMillan, New York, 1939, p. 264.

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