N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546321, C07D21186, A61K 31455

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active

052349357

ABSTRACT:
Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,

REFERENCES:
patent: 3787444 (1974-01-01), Gosteli
patent: 3883543 (1975-05-01), Bossert
patent: 3956341 (1976-05-01), Loev
patent: 3956395 (1976-05-01), Meyer
patent: 4707486 (1987-11-01), Flockerzi et al.
patent: 4780538 (1988-10-01), Pitzenberger
patent: 4975440 (1990-12-01), Flockerzi et al.
Thomas D. Harris, "Ortho Lithiation via a Carbonyl Synthon," J. Org. Chem., vol. 44, No. 12, 1979, pp. 2004-2007.
"Meldrum's Acid in Organic Synthesis 2. A General and Versatile Synthesis of .beta.-Keto Esters," in J. Org. Chem., vol. 43, No. 10, 1978, pp. 2087-2088.
Wesley J. Dale, "The Anomalous Reaction of Methylmagnesium Iodide with the Tosylate of .rho.-Hydroxybenzaldehyde," in J. Am. Chem. Soc. 78, 1956, pp. 2543-2547.
Samuel A. Glickman, "Structure of .beta.-Amino Derivatives of .alpha.,.beta.-Unsaturated Lactones and Esters," J. Am. Chem. 67, 1945, pp. 1017-1020.
Houben Weyl's Methods of Organic Chemistry, vol. VII/4, 1968, p. 230.
Alfred Dornow, "Uber Einige Umsetzungen des Nitroacetons," in Liebig's Ann. Chem. 602, 1957, pp. 14-23.
Loev et al. CA 81:145644.gradient..
Vitolina et al. CA 101:16792z.
Meyer et al. CA 79:146412p, 79:146410m.
Bossert CA 80-14958.
Ogle et al. CA 101:90153h.

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