N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs the

Details N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs the N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs the

1990-05-21

1991-09-03

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 18, 546142, A61K 3144, C07D41714

Patent

active

050455443

ABSTRACT:
This invention relates to N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical perparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes melitus associated complications.

REFERENCES:
patent: 4927831 (1990-05-01), Malamas
Malen et al., Chem. Abst. 100-121065s (1984).
Brittain, Chem. Abst. 105-42767x (1986).

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