N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl

Details N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl

1987-09-02

1988-12-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546161, 564 94, C07D21544, A61K 3147

Patent

active

047896779

ABSTRACT:
New compounds having the formula I ##STR1## where one of A and B is CH or N, the other of A and B is CH, Q is lower alkylene, R is lower alkyl, X.sub.1 is halogen or trifluoromethyl and X.sub.2 and X.sub.3 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkoxy and lower alkyl and the pharmaceutically acceptable acid additions are disclosed as anti-hypertensive agents. New compounds having the formula II ##STR2## where Q, R, X.sub.2 and X.sub.3 are as explained above and n is 0 or 1 and their acid addition salts are useful as intermediates.

REFERENCES:
patent: 3632761 (1972-01-01), Graham et al.
patent: 4025629 (1977-05-01), Coverdale
patent: 4167567 (1979-09-01), McCall
patent: 4235908 (1980-11-01), Boyle
patent: 4640920 (1987-02-01), Boyle
Chemical Abstracts for DE 2,039,233 (2/18/71) 74:99900f (1971), Graham et al.
Chemical Abstracts for JP 124758 (7/25/83), 100:34278v (1984), Fujisawa Pharmaceutical.
Wendling et al., Fed. Proc., 42, 162-166 (1983).

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