N-Alkyl-N-acyl derivatives of thienamycin

Details N-Alkyl-N-acyl derivatives of thienamycin N-Alkyl-N-acyl derivatives of thienamycin

1977-05-05

1980-11-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

2602452T, 424250, 424263, 424269, 424270, 424272, 424273R, 542420, 542426, 542427, 546272, 546122, A61K 3140, C07D48704

Patent

active

042359171

ABSTRACT:
Disclosed are N-alkyl- N-acyl derivatives of the antibiotic thienamycin having the following structural formula: ##STR1## wherein R.sup.1 is, inter alia, alkyl, alkenyl, aryl or aralkyl; and R.sup.2 is acyl. Such compounds, including their O- and carboxyl derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4150145 (1979-04-01), Christinsen et al.
Beecham Group Ltd., Derwent Abstract 72175x 3/16/75.
Beecham Group Ltd., Derwent Abstract 67721w 3/28/74.
Merck & Co. Inc., Derwent Abstract 40282y 11-19-76.
Merck & Co. Inc., Derwent Abstract 40283y 11-19-76.

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