N-alkyl and N-benzyl adriamycin derivatives

Details N-alkyl and N-benzyl adriamycin derivatives N-alkyl and N-benzyl adriamycin derivatives

1985-04-08

1986-09-09

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3171, C07H 1524

Patent

active

046109773

ABSTRACT:
Compounds having the structure ##STR1## in which A is alkanoate having from 4 to 10 carbon atoms, hemiadipate, or hemiglutarate, and R.sub.1 and R.sub.2 are n-propyl, or n-butyl, or R.sub.1 is hydrogen, n-propyl or n-butyl and R.sub.2 is benzyl, and their corresponding non-toxic pharmacologically acceptable acid salts. The compounds are useful as active agents in therapeutic compositions having antitumor activity.

REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 4035566 (1977-07-01), Israel et al.
patent: 4177264 (1979-12-01), Wu et al.
patent: 4250303 (1981-02-01), Wu et al.
patent: 4299822 (1981-11-01), Israel et al.
Arcamone et al., Journal of Medical Chemistry, 1974, vol. 17, No. 3, pp. 335-337.
Tong et al., J. Med. Chem., vol. 22, 912-918, (1979).

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