N-Alkyl-4-(4-pyridinyl)isatoic anhydrides

Details N-Alkyl-4-(4-pyridinyl)isatoic anhydrides N-Alkyl-4-(4-pyridinyl)isatoic anhydrides

1983-08-15

1985-05-07

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

546156, C07D26526, C07D21516

Patent

active

045159459

ABSTRACT:
N-alkyl-4-(4-pyridinyl)isatoic anhydrides are prepared by alkylating a 4-(4-pyridinyl)isatoic anhydride, suitably in the presence of sodium hydride and N,N-dimethylformamide. The products are particularly useful in the preparation of antibacterial 1-alkyl-1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids.

REFERENCES:
patent: 1567731 (1925-12-01), Gunther
patent: 3753933 (1973-08-01), Lesher
patent: 3838156 (1974-09-01), Brundage
patent: 3907808 (1975-09-01), Lesher
patent: 4118557 (1978-10-01), Lesher
Mitscher et al., J. Med. Chem. 1978, vol. 21, No. 5, pp. 485-489.
Hardtmann et al., J. Hetercyclic Chem., vol. 12, 1975, pp. 565-572.

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