N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and phar

Details N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and phar N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and phar

1991-09-27

1994-01-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564347, A61K 31135, C07C32337

Patent

active

052816249

ABSTRACT:
This invention provides N-alkyl-3-phenyl-3-(2-substituted phenoxy)propylamines which are useful to treat neurological disorders associated with norepinephrine imbalance.

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patent: 4626549 (1986-12-01), Molloy et al.
Wong et al., "An New Inhibitor of Norepinephrine Uptake Devoid of Affinity for Receptors in Rat Brain", The Journal of Pharmacology and Experimental Therapeutics, vol. 222, No. 1, 61-65 Mar 26, 1982.
Robertson et al., "Progress in Antidepressant Drugs", Annual Reports in Medicinal Chemistry, Chapter 3, pp. 23-32 (1991).
Chouinard et al., "An Early Phase II Clinical Trial of Tomoxetine (LY139603) in the Treatment of Newly Admitted Depressed Patients", Psychopharmacology, vol. 83:126-128 (1984).

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