N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives a

Details N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives a N-alkenyl-2-hydroxybenzo(b)thiophene-3-carboxamide derivatives a

1985-09-16

1988-11-01

Siegel, Alan

Tools

549 55, A61K 3138, C07D33366

Patent

active

047820802

ABSTRACT:
N-Alkenyl-2-hydroxybenzo[b]thiophene-3-carboxamide derivatives are prepared via treatment of the corresponding unsubstituted carboxamide with appropriate agents, such as aldehydes, ketones, enol ethers, epoxides, acetals or ketals.
These compounds have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and thereby useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory bowel disease, glaucoma or other prostaglandins and/or leukotriene mediated diseases.

REFERENCES:
patent: 3413308 (1968-11-01), Bockstahler
patent: 3862320 (1975-01-01), Thominet
patent: 3907826 (1975-09-01), Stoss et al.
patent: 3954748 (1976-05-01), Thominet
patent: 4260779 (1981-04-01), Bernasconi et al.
patent: 4396621 (1983-08-01), Bernasconi

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