N-acyltetrahydroisoquinoline derivatives

Details N-acyltetrahydroisoquinoline derivatives N-acyltetrahydroisoquinoline derivatives

2005-01-04

2005-01-04

Chang, Ceila (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S238000, C546S146000, C514S252040, C514S307000

Reexamination Certificate

active

06838465

ABSTRACT:
This invention relates to novel compounds represented by the general formula [I]:(wherein, R1and R4are the same or different, and represent hydrogen atoms, lower alkyl groups or the like; R2and R3are the same or different, and represent lower alkoxy groups or lower alkyl groups; R5represents a lower alkyl group or aralkyl group optionally having substituent(s); R6represents a hydrogen atom or a lower alkyl group; X represents O, S or NH; m represents an integer of 0 to 3; n represents an integer of 0 or 1; and Ar represents a phenyl group or heteroaryl group optionally having substituent(s)).The compounds of the invention have an antagonistic action on orexin receptors, and are useful for treatment of appetite abnormality, obesity, sleeping disorder or the like.

REFERENCES:
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Accession No. 2001:904039 CHEMCATS listing of ComGenex Product List, RN 336858-32-3, published in 2001.*
Answer 1 of 15 Registry Copyright 2002 ACS, RN 292028-76-3 Registry, “Ring System Data”.

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