N-acylpyrrolidine derivative and synthesis and use thereof

Details N-acylpyrrolidine derivative and synthesis and use thereof N-acylpyrrolidine derivative and synthesis and use thereof

1986-04-16

1987-10-20

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548530, 548533, 548540, A61K 3140, C07D20708

Patent

active

047014652

ABSTRACT:
The present invention relates to N-acylpyrrolidine derivatives of the general formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1-4 alkyl group or the phenyl group, with the proviso that when R.sup.1 is a hydrogen atom, R.sup.2 is phenoxy group, benzoyl, the phenyl group, or a phenyl group which is mono-substituted by a halogen atom or a C.sub.1-4 alkoxy group, and that when R.sup.1 is a C.sub.1-4 alkyl group or the phenyl group, R.sup.2 is an aralkyl group of 7 to 10 carbon atoms, a C.sub.1-4 alkyl group, the phenyl group or a phenyl group mono-substituted by a halogen atom or a C.sub.1-4 alkoxy group; or R.sup.1 and R.sup.2 together form an unsubstituted benzylidene group or a benzylidene group which may be mono-substituted by a C.sub.1-4 alkoxy group; wherein n is an integer of 0 to 5; and pharmaceutical compositions thereof which are useful as anti-amnesic agents.

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patent: 4479963 (1984-10-01), Gruenfeld
Noller, "Chemistry of Organic Compounds", 3rd. ed., 1965, pp. 150, 151, 197, 268; W. B. Saunders, Co., Phila. & London.
The Proceedings of the 1984 Annual Meeting of "The Agricultural Chemical Society of Japan", pp. 752-754.
Agri. Biol. Chem., 42(12), pp. 2417-2419, 1978.

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