Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-05-18
1996-05-07
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
530322, 548209, 548477, 560155, 560169, 562565, 536 53, 436826, 436823, A61K 3800, A61K 3814, C07K 900, C08K 3700
Patent
active
055146546
ABSTRACT:
N-acyldipeptides of formula I ##STR1## wherein R represents a rest of formula ##STR2## and R.sub.4, Y, m, n and Z have the meaning as defined in the description, R.sub.1 represents hydrogen, a 1-10 C. alkyl, an optionally substituted methyl or benzyl,
R.sub.2 represents a --CO--A group,
wherein A has the meanings as defined in the description,
R.sub.3 represents a --(CH.sub.2).sub.p --CO--W group,
wherein p and W have the meaning as defined in the description.
REFERENCES:
Danklmaier et al., Liebigs Ann. Chem., 145 (1990).
Dollery, et al., The Conduct of Initial Drug Studies in Man, Br. Med. Bull, vol. 26, (1970) pp. 233-235.
Adam, et al., Correlation of Structure and Adjuvant Activity of N-Acetyl Muramyl-L-Alanyl-D-Isoglutamine (MDP), Its Derivatives and Analogues, Anti-Adjuvant and Competition Properties of Stereoisomers, Biochem. Biophys. Res. Commun., vol. 72 (1976), pp. 339-349.
Communications to the Editor, Journal of Medicinal Chem., vol. 24 (1982), pp. 335-337.
Baschang, Muramylpeptides and Lipopeptides: Studies Towards Immunostimulants (1988), pp. 6331-6357.
Honig, et al., Syntheses of Polymeric Vesicles Containing Partial Structures of N-Acetyl-Muramyl-Dipeptide (MDP), Chem. and Phys. of Lipids, vol. 53 (1990), pp. 347-356.
Adam, et al., Muramyl Peptides: Immunomodulators, Sleep Factors, and Vitamins, Medicinal Rev., vol. 4 (1984), pp. 111-152.
Ihan Alojz
Kikelj Danijel
Klamfer Lidija
Kopitar Zdravko
Kotnik Vlado
Huff Sheela J.
Warden Jill
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