N-acylated derivatives of polyethyleneimine bonded phase silica

Details N-acylated derivatives of polyethyleneimine bonded phase silica N-acylated derivatives of polyethyleneimine bonded phase silica

1990-03-13

1991-11-19

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502401, B01D 1508

Patent

active

050663950

ABSTRACT:
Sulfonic derivatives of N-acylated covalently bound, non-crosslinked polyethyleneimine bonded phase silicas of the formula: ##STR1## wherein ##STR2## is the backbone of a silica gel or glass, n is an integer such that the polyethyleneiminopropyl silane group has an average molecular weight of from about 400 to about 1800; q is an integer of zero or one; R is selected from the group consisting of hydrogen, --CH.sub.2).sub.x H or --CH.sub.2).sub.m COOH where X is an integer of 1 or 2 and m is an integer of zero or 1; when R is hydrogen or --CH.sub.2).sub.x H then R.sup.1 is --CH.sub.2).sub.p COOH where p is an integer of zero or 1, and when R is --CH.sub.2).sub.m COOH then R.sup.1 is selected from the group consisting of hydrogen or --CH.sub.2).sub.y H where y is an integer of zero or 1, are especially useful as solid phases for the purification and separation of proteins having isoelectric points of below about 5.

REFERENCES:
patent: 3873514 (1975-03-01), Chu
patent: 3987058 (1976-10-01), Saunders
patent: 4140653 (1979-02-01), Imura
patent: 4362818 (1982-12-01), Cornelius
patent: 4469630 (1984-09-01), Flashner
patent: 4505818 (1985-03-01), Mukoyama
patent: 4523997 (1985-06-01), Crane
patent: 4540486 (1985-09-01), Ramsden
patent: 4551245 (1985-11-01), Ramsden
patent: 4606825 (1986-08-01), Crane
patent: 4640909 (1987-02-01), Ramsden
patent: 4650784 (1987-03-01), Ramsden
patent: 4661248 (1987-04-01), Ramsden
patent: 4680120 (1987-07-01), Ramsden
patent: 4680121 (1987-07-01), Ramsden
patent: 4694050 (1987-09-01), Fairchok
patent: 4721573 (1988-01-01), Ramsden
Gupta, High-Performance Cation Exchange Chromatography of Proteins, Analytical Biochemistry 128, (1983), pp. 196-201.

Affiliated with

Also associated with

Rating

N-acylated derivatives of polyethyleneimine bonded phase silica does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-acylated derivatives of polyethyleneimine bonded phase silica , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-acylated derivatives of polyethyleneimine bonded phase silica will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1368207