N-acylated derivatives of mixtures of amino acids derived from h

Details N-acylated derivatives of mixtures of amino acids derived from h N-acylated derivatives of mixtures of amino acids derived from h

1993-11-16

1995-10-17

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

554 61, 554 63, 562516, A61K 600, A61K 700

Patent

active

054588812

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

The present invention relates to new N-acylated derivatives from mixtures of amino acids derived by total hydrolysis of proteins of plant origin and their salts, as well as their application to the field of cosmetics and detergents.


BACKGROUND

At the present time, N-acylated derivatives of mixtures of amino acids obtained by hydrolysis of proteins of animal origin are currently employed for cosmetic purposes.
Because of the their amphiphilic structure, these polyacylated lipoamino acids can progress rapidly through the first cell layers either to restore deficient structures or to release their active ingredients within the epidermis.
Hence these lipoamino acid structures are particularly useful biological vectors as skin physiology regulators and prove to be appropriate for multiple applications, particularly in cosmetics.
The sources of these amino acid mixtures are today essentially collagen, elastin, keratin, and casein.
In view of their animal origin, these hydrolysates unfortunately have potential risks of contamination by pathogens which it would be desirable to avoid; users tend with increasing frequency to avoid animal-derived compounds for any application intended for human beings.
Moreover, British Patent No. 1,153,408 describes N-acylated derivatives of mixtures of amino acids obtained by hydrolysis of proteins of plant origin. However, the precise nature of these proteins is not described. Moreover, the present inventors have been able to ascertain that depending on the nature of the plant from which the protein is derived, the resulting compounds can have very different properties. They thus observed that N-acylated derivatives of mixtures of amino acids from hydrolysates of leguminous proteins such as soy had certain disadvantages.
Thus, solutions of such N-acylated derivatives, particularly solutions of salts of these derivatives, have relatively substantial coloration, which is troublesome in certain applications, particularly in the field of cosmetics. Moreover it is often necessary to locate the pH of cosmetic compositions at approximately 5.5, namely at a pH approximately that of the skin, to decrease their aggressiveness to the skin. Now the inventors have ascertained that solutions containing such N-acylated derivatives of leguminous proteins such as soy become cloudy as soon as their pH drops lower than approximately 6.8. Yet one important and frequently sought-after characteristic of cosmetic compositions is their clarity.
Moreover, said derivatives derived in particular from soy proteins have a relatively high ability to increase viscosity in an aqueous solution, which sometimes makes it difficult to prepare certain compositions, particularly cosmetic compositions, with the aid of such solutions.


SUMMARY OF THE INVENTION

Thus the present invention has as an object novel N-acylated derivatives of mixtures of amino acids derived from plant proteins, which allow very low-color solutions that are stable even at a pH of approximately 5.5 and have a relatively low ability to increase viscosity in an aqueous solution to be obtained.
Another object of the invention is cosmetic compositions containing said derivatives, which compositions have a cosmetic activity comparable or even superior to compositions containing N-acylated derivatives of mixtures of amino acids derived from animal protein hydrolysates.
A third object of the present invention is detergent compositions containing said N-acylated derivatives.
Hence the invention comprises new N-acylated derivatives of mixtures of amino acids with general formula I: ##STR1## wherein R represents a saturated or unsaturated, linear or branched radical with C.sub.4 to C.sub.30, and derivatives of amino acid mixtures, which amino acid mixtures are derived from cereal protein hydrolysates.


DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION

According to one advantageous feature of the present invention, R represents a radical with C.sub.7 to C.sub.19, and more particularly R represents a radical with C.sub.7, C.sub.11,

REFERENCES:
patent: 3927047 (1975-12-01), Ichikawa et al.
patent: 3985722 (1976-10-01), Yoshida et al.
patent: 4828824 (1989-05-01), Grollier

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