N-acylated 4-hydroxphenylamine derivatives with analgesic proper

Details N-acylated 4-hydroxphenylamine derivatives with analgesic proper N-acylated 4-hydroxphenylamine derivatives with analgesic proper

1995-04-21

1996-09-10

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548210, A61K 31425, C07D27506

Patent

active

055546366

ABSTRACT:
The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group, of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.

REFERENCES:
patent: 4116964 (1978-09-01), Zinnes et al.

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