N-acylamino acid derivatives and their pharmaceutical compositio

Details N-acylamino acid derivatives and their pharmaceutical compositio N-acylamino acid derivatives and their pharmaceutical compositio

1988-09-06

1992-06-16

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 5142378, 514315, 514317, 514319, 514365, 514372, 514428, 514514, 540610, 544 59, 544159, 544168, 546205, 546242, 546247, 548146, 548214, 548568, 560129, 564162, 564163, 564197, A61K 3154, C07D29513

Patent

active

051225239

ABSTRACT:
An N-acylamino acid derivative of the formula: ##STR1## wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

REFERENCES:
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Bolis et al, J. Med. Chem., 1987, 30, 1729-1737.
Haber et al, J. Cardiovascular Pharmacology, 10 (Suppl. 7):554-558 1987.
Plattner et al, J. Med. Chem, 1988, 31, 2277-2288.
Denkewatter et al, Progress in Drug Research, 1966, 510-515.
Burger, Medicinal Chemistry 2nd ed, Interscience Publishers 1960, pp. 565-5571, 579-581, 600, 601.
Patent Abstracts of Japan, unexamined applications, C field, vol. 11, No. 136, Apr. 30, 1987, p. 161 C 419 (Sankyo), Kokai-No. 61-275 258.
Patent Abstracts of Japan, unexamined applications, C field, vol. 11, No. 349, Nov. 14, 1987, p. 46 C 456 (Kissei Pharmaceut) Kokai-No. 62-120 370.

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