N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514310, 514241, 514253, 514269, 544215, 544333, 544405, 546146, 546147, A61K 3147, C07D21700

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active

051243377

ABSTRACT:
N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R.sup.1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diphenylamino; di-(R.sup.2 -substituted phenyl)amino; di-(heteroaryl)amino; di-R.sup.2 -substituted heteroary)amino; diphenylmethyl; or di-(R.sup.2 -substituted phenyl)methyl;

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Stenlake et al., Eur. J. Med. Chem.-Chim. Ther., 9(3), 239-242 (1974), Chemical Abstracts 82(9):57976v.

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