N-Acyl-polypeptides and processes for the production thereof

Details N-Acyl-polypeptides and processes for the production thereof N-Acyl-polypeptides and processes for the production thereof

1982-03-02

1984-03-06

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125S, A61K 3700, C07C10352

Patent

active

044353855

ABSTRACT:
N-Acyl-polypeptides comprising the basic sequence ##STR1## wherein "Acyl" is the acyl residue of an organic or inorganic acid; A is H or alkyl; >N--CH(Z)--CO-- and E are the residues of natural .alpha.-amino acids or corresponding (D)-amino acids; C is --Trp-- or --(D)Trp--; F is a terminal grouping; and Y.sub.1 and Y.sub.2 are each H or together are a direct bond; as well as their salt forms and complexes.

REFERENCES:
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 4282143 (1981-08-01), Sarantakis

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