N-acyl peptide, processes for their preparation and pharmaceutic

Details N-acyl peptide, processes for their preparation and pharmaceutic N-acyl peptide, processes for their preparation and pharmaceutic

1982-12-23

1987-02-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 560149, 560222, 560251, 560252, 560253, 560169, 560170, 2609982, 514 19, A61K 3743, C07K 506, C07K 508, C07C14312, C07C 6952, C07C 6702, C07C10126, C07C10130

Patent

active

046439900

ABSTRACT:
N-acylpeptides are disclosed of the formula: ##STR1## wherein R.sup.1 is alkanoyloxy or alkenoyloxy; R.sup.2 is alkyl or alkenyl; R.sup.3 and R.sup.4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carboxy(lower)alkyl, carboxy(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl; R.sup.5 is hydrogen, hydroxy(lower)alkyl, protected amino(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl; R.sup.6 is carboxy, esterified carboxy or sulfo(lower)alkyl; A.sup.1, A.sup.2 and A.sup.3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; or its pharmaceutically acceptable salt. These compounds have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immune-complex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism, etc.

REFERENCES:
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patent: 3893992 (1975-07-01), De Benneville
patent: 4205069 (1980-05-01), Beluzzi et al.
patent: 4221675 (1980-09-01), Schirmann et al.
patent: 4311640 (1982-01-01), Kuroda et al.
patent: 4436726 (1984-03-01), Umehara et al.
Derwent Publications & JP A 67 11 925, 1967.
Derwent Publications & JP A 71 08 685, 1971.
Derwent Publications & JP A 71 00 164, 1971.
Yasutaka Tahara, Masaru Kameda, Yuzo Yamada and Keiji Kondo, Agricultural and Biological Chemistry, 40(1), 243-244, 1976.

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