N-acyl-N′-benzyl-alkylendiamino derivatives

Details N-acyl-N′-benzyl-alkylendiamino derivatives N-acyl-N′-benzyl-alkylendiamino derivatives

2004-11-12

2008-08-12

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S408000, C514S423000, C514S625000, C548S400000, C548S530000

Reexamination Certificate

active

07411091

ABSTRACT:
This invention is related to compounds and use of N-Acyl-N′-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C2-C8alkyl chain; X is a methylene, oxygen, sulphur or a NR7group; R1is a straight or branched C1-C8alkyl or C3-C8alkenylene or C3-C8alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4alkyl, halogens, trifluoromethyl, hydroxy or C1-C4alkoxy groups; R2, R3are independently hydrogen, a C1-C3alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4alkoxy groups; R4, R5are independently hydrogen or C1-C6alkyl; R6is a hydrogen or a straight or branched C1-C8alkyl or linked to R5can form a five to seven membered lactam; R7is hydrogen or C1-C6alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role

REFERENCES:
patent: WO 99/35123 (1999-07-01), None
patent: WO 99/35125 (1999-07-01), None
D Nation et al: “Asymetric copper complexes of stable mono-t-butyl monobenzyl dithioether N2S2 ligands” J. Chem. Soc. Dalton Trans, vol. 14, 1996, pp. 3001-3009, XP009025876 cited in the application, see compound 3 and p. 3007, top right hand.
Saikawa et al: “Studies on beat lactam antibiotics for medicinal purpose VIII” Yakugaku Zasshi, vol. 99, No. 9, 1979, pp. 929-935, XP009025875 see compound V1 and p. 934934, 3rdline from the bottom, Na-cetyl-N′Dmb ethylenediamine.
Menage et al: “02 activation and aromatic hydroxylation performed by diiron complex” J American Chemical Society, vol. 120, No. 51, 1998, pp. 13370-13382, XP002270206 see p. 13373, rh col. b) L7b).
Al-Obaid et al: “Synthesis and anticonvulsant activity of some 1-substituted-2-oxopyrrolidine derivatives” Medicinal Chemistry Research, vol. 9, No. 9, 1999, pp. 696-721, XP009025675 see compounds Figure 1 and p. 697 lines 4, 5.

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