Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1997-04-15
Northington Davis, Zinna
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, 514419, 514443, 514469, 548252, 548253, 548496, 548504, 549 49, 549 58, 549467, C07D40502, A61K 3134
Patent
active
056209983
ABSTRACT:
The invention relates to N-acyl-N-heterocyclylalkylamino acids of the formula ##STR1## wherein Y.sub.1 is O, S or N(R) and R is hydrogen or C.sub.1 -C.sub.7 alkyl;
X.sub.1 is --CO-- or --S(O).sub.m -- and the index m is 0, 1 or 2;
one of the variables X.sub.2 and X.sub.4 is C.sub.1 -C.sub.4 alkylene and the other of the variables X.sub.2 and X.sub.4 is a bond; or each of the variables X.sub.2 and X.sub.4 is a bond;
X.sub.3 is C.sub.3 -C.sub.7 cycloalkylidene or the structural element --C(X.sub.a)(X.sub.b)-- and X.sub.a is hydrogen or C.sub.1 -C.sub.7 alkyl and X.sub.b is C.sub.1 -C.sub.7 alkyl;
and the rings A, B and C, with the exception of the substituents indicated in the formula, and also aromatic substituents are, independently of one another, unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of halogen, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy, C.sub.2 -C.sub.7 alkenyloxy, phenoxy, benzyloxy, trifluoromethyl and S(O).sub.m --R, wherein m is 0, 1 or 2 and R is hydrogen or C.sub.1 -C.sub.7 alkyl;
or a salt thereof.
REFERENCES:
patent: 4006239 (1977-02-01), Mayer et al.
patent: 5096897 (1992-03-01), Boshagen et al.
patent: 5191092 (1993-03-01), Niewohner et al.
Derwent Abstract 54175R, 1970 of BE 745,065.
Derwent Abstract 91-254550, 1991 of EP 443,983.
European Patent Office Search Report Nov. 23, 1992.
B uhlmayer Peter
Schmidlin Tibur
Zbinden Paul
Ciba-Geigy Corporation
Davis Zinna Northington
Ferraro Gregory D.
Kaiser Karen G.
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