N-acyl dipeptides and their compositions

Details N-acyl dipeptides and their compositions N-acyl dipeptides and their compositions

1994-02-10

1996-07-09

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514419, 514397, 514385, 514563, 514414, 4352402, 43524025, C07C23300, C07C23324, C07C23334, A61K 31415, A61K 31405, A61K 3116

Patent

active

055345387

ABSTRACT:
Novel a-acyl dipeptides of the formula:

REFERENCES:
Blodgett et al, "Direct Cleavage versus Transpeptidation in the Autodecomposition of Peptides Containing 2,4-Diaminobutanoic Acid (DABA) and 2,3-Diaminopropanoic Acid (DAPA) Residues. Specific Cleavage of DAPA-Containing Peptides", Journal of the American Chemical Society, Aug. 1989, pp. 6813-6821.
Kobayashi et al, "Acyl-peptide Hydrolase from Rat Liver: Characterization of Enzyme Reaction", Journal of Biological Chemistry, Aug. 1987, pp. 11435-11445.
Bizzozero et al, "Serine-Protease-Assisted Synthesis of Peptide substrates of .alpha.-Chymotrypsin", Helvetica Chimica Acta, Sep. 1982, pp. 1707-1719.
Chemical Abstracts, vol. 110, No. 5, Jan. 30, 1989.
Patent Abstracts of Japan, Nov. 26, 1990, re: JP-A-02 286 624.
"Polymers Containing Enzymatically Degradable . . . " in Makromol, Chem., 182, 799-809 (1981).
"Polymers Cont. Enzymatically Degrad. Bonds . . . " in Makromol. Chem., 182, 1899-1915 (1981).
"Reactive Copolymers of N-(2-Hydroxypropyl) . . . " Makromol. Chem, 178, 2169-2183 (1977).
"Acyl-peptide Hydrolase from Rat Liver" in the Journal of Biol. Chem. 1987 vol. 262, No. 24, Aug. 25, pp. 11435-11445, 1987 by Kazumi Kobayashi and John A. Smith.
"Inhibition by Bestatin of a Mouse Ascites Tumor Dipeptidase" in the Journal of Biol. Chem. (1989) vol. 264, No. 14, Issue of May 15, pp. 8004-8011. (1989) by Elizabeth K. Patterson.
Chemical Abstracts, vol. 85, 1976 p. 578.
Chemical Abstracts, vol. 111, 1989, p. 23.
Chemical Abstracts, vol. 107, 1987, p. 350.
Gas Registry Handbook pp. 99976-95-1 258RO; Number section 1433RM (1984 Supplement).

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