N-Acyl derivatives of glucosamines having antitumor chemotherape

Details N-Acyl derivatives of glucosamines having antitumor chemotherape N-Acyl derivatives of glucosamines having antitumor chemotherape

1978-07-31

1980-08-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 424180, 536 53, A61K 3700, C07C10352, A61K 3170

Patent

active

042162084

ABSTRACT:
N-Acyl derivatives of glucosamines made by linking an amino acid or oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl group, to the amino group of the glucosamines by a peptide bond, are endowed with strong anti-tumor action against transplanted neoplasma in animal. The compounds according to the present invention are of the general formula (I): ##STR1## where R.sub.1 is a hydrogen atom or an acetyl group,

REFERENCES:
Siggins et al., J.A.C.S. 1966, pp. 971-973.
Adam et al., Biochem. and Biophys. Res. Commun. 72, 1976, pp. 339-346.

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