N-Acyl derivatives of glucosamine having antitumor chemotherapeu

Details N-Acyl derivatives of glucosamine having antitumor chemotherapeu N-Acyl derivatives of glucosamine having antitumor chemotherapeu

1980-07-30

1982-02-09

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 424180, 536 4, 536 18, 536 53, A61K 3702, C07C10352

Patent

active

043149995

ABSTRACT:
N-acyl derivatives of D-hexosamine made by linking an oligopeptide having a m-di(2-chloroethyl)amino-L-phenylalanyl residue to the amino groups of two hexosamine molecules by a peptide bond, are endowed with strong antitumor action against transplanted neoplasms in animals. Compounds according to the present invention are: ##STR1## and its salts with organic or inorganic acids physiologically tolerated. The antineoplastic activity of the compounds of the present invention is not affected in the gastrointestinal tract and hence they can be effectively administered orally.

REFERENCES:
patent: 4211866 (1980-07-01), Matsumura et al.
patent: 4216208 (1980-08-01), De Barbieri
patent: 4220643 (1980-09-01), Suami
patent: 4229440 (1980-10-01), Murofushi et al.
patent: 4232149 (1980-11-01), Paegle et al.
patent: 4237266 (1980-12-01), Sugiura et al.
patent: 4239905 (1980-12-01), Kodama et al.
patent: 4241052 (1980-12-01), Tsujihara et al.
patent: 4243663 (1981-01-01), Azuma et al.
patent: 4248999 (1981-02-01), Baba et al.
patent: 4254110 (1981-03-01), Cassinelli et al.
Chaturvedi et al., J.A.C.S. 1966, pp. 971-973.
Adam et al., Biochem. and Biophys. Res. Commun. 72, 1976, pp. 339-346.
Gregoriadis, Nature, Feb. 3, 1977, vol. 265, pp. 407-410.
De Barbieri, Current Chemotherapy, American Society of Microbiology, Apr. 1978, pp. 1183-1185.

Affiliated with

Also associated with

Rating

N-Acyl derivatives of glucosamine having antitumor chemotherapeu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-Acyl derivatives of glucosamine having antitumor chemotherapeu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-Acyl derivatives of glucosamine having antitumor chemotherapeu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1260596