Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-07-19
1983-11-08
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544120, 544359, 544409, 4142484, A61K 31495, C07D24116, C07D24120
Patent
active
044142153
ABSTRACT:
N-Acyl derivatives of 6-(alkylamino)-5-chloro-3-nitro-pyrazinamines are disclosed to have activity in increasing the sensitivity of tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
REFERENCES:
patent: 3541093 (1970-11-01), Tull et al.
patent: 3660397 (1972-02-01), Jones et al.
Ainsworth, et al., Canadian J. Biochemistry, vol. 56 (1978), pp. 457-461.
Adams, et al., The Lancet (Jan. 1976), pp. 186-188.
Olive, Peggy, Cancer Research, vol. 39, (Nov. 1979), pp. 4512-4515.
Anderson, et al. British J. of Cancer, vol. 37, (1978), pp. 103-106.
Arther Thomas E.
Berch Mark L.
Hendricks G.
Merck & Co. , Inc.
Monaco Mario A.
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