N-acyl derivatives of 3-amino-2,4,6-triiodobenzoic acid

Details N-acyl derivatives of 3-amino-2,4,6-triiodobenzoic acid N-acyl derivatives of 3-amino-2,4,6-triiodobenzoic acid

1977-08-31

1979-05-01

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

424 5, C07C101447, A61K 2902

Patent

active

041525264

ABSTRACT:
N-acyl derivatives of 3-amino-2,4,6-triiodobenzoic acid having the formula ##STR1## in which R.sub.1 is hydrogen, alkyl of up to 4 carbon atoms, alkoxyalkyl of 2-5 carbon atoms or alkoxyalkoxyalkyl of 3-8 carbon atoms, R.sub.2 is alkylene of up to 5 carbon atoms, R.sub.3 is alkylene of up to 3 carbon atoms, R.sub.4 is alkyl of up to 6 carbon atoms, X is straight chain or branched alkylene with two or three carbon atoms in the main chain and n is 0, 1 or 2 and the pharmaceutically acceptable salts thereof, which are useful as X-ray contrast media for intravenous cholecystographie.

REFERENCES:
patent: 2587936 (1952-03-01), Wollingford
patent: 3042715 (1962-07-01), Obendorf et al.
patent: 3389170 (1968-06-01), Habicht
patent: 3484481 (1969-12-01), Obendorf et al.
patent: 3803221 (1974-04-01), Ackerman

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