N-acyl beta amino acid derivatives useful as platelet aggregatio

Details N-acyl beta amino acid derivatives useful as platelet aggregatio N-acyl beta amino acid derivatives useful as platelet aggregatio

1995-08-24

1998-01-20

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514357, 514637, 546194, 546332, 564246, A61K 31445, C07D40112, C07D21156

Patent

active

057101663

ABSTRACT:
Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.

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patent: 5344957 (1994-09-01), Bovy
Banner et al. "Serine proteases:3D structures, mechanisms of action and inhibitors" Perspect. Med. Chem. Verlag, pp.27-43, 1993.
Hartman et al "Nonpeptide Fibrinogen Receptor Antagonist" J. Med. Chem. 35 4640-4642 (1992).
Rubini et al "Synthesis of Isosteric Methylene-oxy Pseudopeptide Analogues as Novel Amide Surrogate Units" Tetrahedron 42 6039-45 (1986).

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