N-acryloylpiperazine derivatives, their preparation and their us

Details N-acryloylpiperazine derivatives, their preparation and their us N-acryloylpiperazine derivatives, their preparation and their us

1991-08-28

1993-03-09

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514253, 540607, 544237, 544238, 544284, 544298, 544335, 544353, 544354, 544355, 544362, 544363, 544367, 544368, 544375, 544376, 544379, 544380, 544383, 544386, 544387, 544391, A61K 31495, C07D24104

Patent

active

051927667

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 is each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5, wherein R.sup.5 is optionally substituted aryl or aromatic heterocyclic; R.sup.3 is hydrogen, alkyl, cyano or --R.sup.5 ; X is oxygen or sulfur; A is 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R.sup.4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the piperazine or homopiperazine part of the molecular with a compound containing the other part of the molecule.

REFERENCES:
patent: 4788206 (1988-11-01), Guthrie et al.
patent: 4794183 (1988-12-01), Nakamura et al.
patent: 4891363 (1990-01-01), Nakamura et al.
patent: 5068340 (1991-11-01), Nakamura et al.

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