N-acryloylpiperazine derivatives, their preparation and their us

Details N-acryloylpiperazine derivatives, their preparation and their us N-acryloylpiperazine derivatives, their preparation and their us

1992-11-06

1994-11-29

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540575, A01N 4342, C07D24308

Patent

active

053691067

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 is each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5, wherein R.sup.5 is optionally substituted aryl or aromatic heterocyclic; R.sup.3 is hydrogen, alkyl, cyano or --R.sup.5 ; X is oxygen or sulfur; A a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl; and R.sup.4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity, and may be prepared by reacting a compound containing the homopiperazine part of the molecule with a compound containing the other part of the molecule.

REFERENCES:
patent: 4788206 (1988-11-01), Guthrie et al.
patent: 4794183 (1988-12-01), Nakamura et al.
patent: 4891363 (1990-01-01), Nakamura et al.
patent: 5068340 (1991-11-01), Nakamura et al.

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