Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-07
1996-09-17
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514255, 540575, 544384, 544387, 544391, 544400, A01N 4362, A01N 4360, C07D74104
Patent
active
055568521
ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 is each --R.sup.5, --CH.dbd.CH--R.sup.5 or --C.tbd.C--R.sup.5, wherein R.sup.5 is optionally substituted aryl or aromatic heterocyclic; R.sup.3 is hydrogen, alkyl, cyano or --R.sup.5 ; X is oxygen or sulfur A is 1,4-piperazin-1,4-diyl or a 1,4-homopiperazin-1,4-diyl; B' is alkylene, carbonyl, thiocarbonyl, sulfinyl or sulfonyl: and R.sup.4 is optionally substituted phenyl and pharmaceutically acceptable salts thereof have valuable PAF antagonist activity.
REFERENCES:
patent: 4788206 (1988-11-01), Guthrie et al.
patent: 4794183 (1988-12-01), Nakamura et al.
patent: 4891363 (1990-01-01), Nakamura et al.
patent: 5068340 (1991-11-01), Nakamura et al.
Iijima Yasuteru
Miyamoto Masaaki
Nakamura Norio
Ohkawa Nobuyuki
Oshima Takeshi
Covington Raymond
Ivy C. Warren
Sankyo Company Limited
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