Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2008-01-29
2008-01-29
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S183000, C435S252300, C435S320100, C530S350000, C536S023200
Reexamination Certificate
active
10492819
ABSTRACT:
Described are an enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through a β1,3-linkage; nucleic acid coding for the enzyme; and method for diagnosis of a cancer and/or tumor, especially a cancer and/or tumor of a digestive organ using the expression amount of the gene of the enzyme as an index. A gene coding for a novel enzyme having an activity to transfer N-acetylglucosamine to N-acetylgalactosaminyl group through the β1,3-linkage was cloned from human colon and stomach cells, and the gene was sequenced. The enzyme was expressed, and a monoclonal antibody to the enzyme was prepared. Since this enzyme is not produced substantially or at all in cancer and/or tumor cells, especially in cancer or tumor cells of a digestive organ, the cancer and/or tumor may be diagnosed using the expression of the gene of the enzyme as an index.
REFERENCES:
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patent: WO 02/064795 (2002-08-01), None
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Inaba Niro
Iwai Toshie
Narimatsu Hisashi
Birch & Stewart Kolasch & Birch, LLP
Fronda Christian L.
National Institute of Advanced Industrial Science and Technology
Saidha Tekchand
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