Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2007-05-29
2007-05-29
Rao, Manjunath N. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S006120, C435S101000, C435S183000, C435S069100, C435S320100, C435S325000, C536S023200
Reexamination Certificate
active
10507421
ABSTRACT:
An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
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Inaba Niro
Narimatsu Hisashi
Togayachi Akira
Chowdhury Iqbal
National Institute of Advanced Industrial Science and Technology
Rao Manjunath N.
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