N-acetyl-.beta.-d-glucosamine derivatives and reagents for deter

Details N-acetyl-.beta.-d-glucosamine derivatives and reagents for deter N-acetyl-.beta.-d-glucosamine derivatives and reagents for deter

1991-12-13

1993-12-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 176, 536 181, 536 53, 536122, 435 18, 435 4, C07H 1524, C07H 1700

Patent

active

052740862

ABSTRACT:
N-Acetyl-.beta.-D-glucosamine derivatives represented by the formula ##STR1## wherein R.sup.1 denotes a substituted alkyl group of 1 to 4 carbon atoms having a hydroxyl group, carboxyl group, sulfonic acid group or phosphoric acid group, or an alkali metal salt thereof, or a substituted phenyl group having a hydroxyl group, carboxyl group, sulfonic acid group, phosphoric acid group or said substituted alkyl group, or an alkali metal salt thereof, and R.sup.2, R.sup.3 and R.sup.4 each independently denote a hydrogen atom, halogen atom or nitro group, a process for producing the same, reagents for determining N-acetyl-.beta.-D-glucosaminidase activity containing said derivatives as effective ingredients, and a method for determining N-acetyl-.beta.-D-glucosaminidase activity using said derivatives.

REFERENCES:
patent: 3524844 (1970-08-01), Keller-Juslen
patent: 5030721 (1991-07-01), Kasai et al.
"Methods in Enzymology", vol. 28, pp. 702-713 (1972).
Dance, N., et al., "Clinica Chimica Acta", vol. 24, pp. 189-197 (1969).
Noto, A., et al., "Clin. Chem.", vol. 29, No. 10, pp. 1713-1716 (1983).
Makise, J., et al., "Clin. Chem.", vol. 34, No. 10, pp. 2140-2143 (1988).

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