N-acetyl-5,6-dimethoxytryptamine and its free radical scavenging

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548496, A61K 31404, C07D20920, A01N 900, A01N 2516, A01N 2528

Patent

active

061143731

ABSTRACT:
The invention involves a novel chemical compound, N-acetyl-5,6-dimethoxytryptamine (compound I), which can also be defined as a melatonin derivative. The molecular weight of compound I is 262 and the chemical structure is as follows. ##STR1## Compound I possesses potent in vitro and in vivo free radical scavenging capacity and exhibits protective effects against convulsions and brain damage induced by oxidative stress. It holds potential clinical usage for preventing and treating diseases which involve free radicals and oxidative stress.

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patent: 5756507 (1998-05-01), Goulet et al.
CA 129: 302483 Melatonin Receptor Ligands: Synthesis . . . Study, Mor et al, 1998.
CA 127: 12976 1-(2-Alkanamidoethyl)-6-methoxyindole Derivatives: A . . . Analogs, Tarzia et al, 1997.

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