Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-06-20
2006-06-20
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07063945
ABSTRACT:
The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
REFERENCES:
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patent: 0 680 969 (1998-11-01), None
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Seela, et al., 2000 “Base-Pairing Properties of 8-Aza-7-deazaadenine Linked via the 8-Position to the DNA Backbone.”Helvetica Chimica Acta, 83:1437-1453.
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Seela, et al., 1989 “96. 2'—Deoxy-B-D-ribofuranosides of N6 -Methylated 7-Deazaadenine and 8-Aza -7-deazaadenine: Solid-Phase Synthesis of Oligodeoxyribonucleotides and Properties of Self-Complementary Duples.”Helvetica Chimica Acta, 72(14):868-881.
Seela, et al., 1988 “193. 8-Aza-7-deazaadenine N8—N9 -(p-d-2'-Deoxyribofuranosides): Building Blocks for Automated DNA synthesis and Properties of Oligodeoxyribonucleotides.”Helvetica Chimica Acta,71:1813-1823.
Bergmann Frank
Debelak Harald
Der Eltz Herbert Von
Heindl Dieter
Seela Frank
Doyle Charles M.
Riley Jezia
Roche Molecular Systems, Inc
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