N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]

Details N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl] N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]

1989-03-20

1991-02-19

Elmore, Carolyn S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435129, 435130, 435897, C12P 1304, C12P 1100, C12P 1302

Patent

active

049943812

ABSTRACT:
Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

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Walter, Justus Liebigs Ann. Chem., pp. 1584-1597 (1976).

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